Boxoffice wrote: "Unrelievedly concerned with the by-now familiar characterization of the mad scientist bent on preserving his fantastic schemes for the ostensible good of future mankind, this Rex Carlton production is on a par with predecessor attractions, director Joseph Green's screenplay providing little unanticipated developments from fade-in to fade-out." On
Rotten Tomatoes, the film holds an approval rating of 38% based on , with a
weighted average rating of 4.63/10. Author and film critic
Leonard Maltin awarded the film 1.5 out of four stars, calling it "poorly produced". On his website
Fantastic Movie Musings and Ramblings, Dave Sindelar gave the film a mostly negative review, noting that, although it managed to work up a certain amount of tension and featured some good gore effects, it was ruined by its lack of likable and intelligent characters and its "inability to decide just how it wants to be taken".
TV Guide awarded the film two out of four stars, calling it "one of the most genuinely bizarre 'brain' movies".
Adaptations The movie also inspired the musical stage production ''The Brain That Wouldn't Die! In 3D!!!'' by Tom Sivak and Elizabeth Gelman, that premiered at the
New York Musical Theatre Festival in October 2011. In 2015, Pug Bujeaud's musical theatrical production ''The HEAD! That Wouldn't Die'' was mounted in
Olympia, Washington by Theater Artists Olympia. Lyrics and music were written by the ensemble cast and the TAO collective. Soon thereafter, Hollywood screenwriter Bruce Bernhard adapted the script as a staged musical comedy, creating a completely new score for it with songwriter Chris Cassone. The official world premiere for
The Brain That Wouldn’t Die!…the Musical was at the Footlight Players Theatre in
Charleston, South Carolina on October 13, 2016. A
satirical feature film adaptation of the same title was filmed on location in
Portland, Oregon. The film premiered on June 21, 2020, as part of the Portland Horror Film Festival. == In popular culture ==