The story centers on a local marine biologist, Doc, and his relationship with Mack and friends, a group of unemployed men, and other residents in the sardine-canning district of Monterey, California. Mack and his buddies are looking to do something nice for their friend Doc, who has been good to them without asking for reward. Mack hits on the idea that they should throw a thank-you party, and the entire community quickly becomes involved. Unfortunately, the party rages out of control, and Doc's lab and home are ruined—and so is Doc's mood. In an effort to return to Doc's good graces, Mack and the boys decide to throw another party—but make it work this time. ,
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Main characters Doc is a marine biologist who runs a biological specimen business, Western Biological Laboratories, who collects, prepares and markets specimens of fish and mammals for research and dissection. He pays bounties for certain creatures he needs, like cats and frogs. In addition to keeping live creatures on the premises, Doc prepares the specimens in his laboratory that also serves as his living quarters. Doc was based on Steinbeck's friend
Ed Ricketts, a marine biologist and entrepreneur.
Lee Chong, an immigrant from China, owns and personally operates the grocery store across from Doc's lab, "Lee Chong's Heavenly Grocery". His store supplies all the needs of the denizens of Cannery Row. Lee Chong was inspired by Won Yee, an immigrant from China who operated the Wing Chong Company Grocery. Won pioneered the drying and preparation of squid, which was exported to China. Won died in 1934.
Dora Flood is the owner and proprietor of the Bear Flag Restaurant, the most prominent and busiest bordello in Monterey. She is a whore with a heart of gold who greatly benefits the community with her public and private charity. Dora Flood is based on Flora Woods Adams, a bordello owner who also figures in Steinbeck's earlier novel
Tortilla Flat and in
East of Eden.
Mack is a seemingly homeless person who is the
de facto leader of a group of other homeless men that congregate in Cannery Row. Mack negotiates with Lee Chong for the occupancy of a storage shack where he and the boys can live, which is fixed up and dubbed "The Palace Flophouse". His character was based on Cannery Row denizen Harold Otis "Gabe" Bicknell. A photo of Bicknell was used on the cover of the 1994 paperback edition of the novel.
Hazel, a simple minded but good hearted-young man who was given a female name by a mother too tired from child-bearing to realize her error at first or subsequently to care, is the most prominent of Mack's boys.
Henri is a painter and visual artist who creates works of art out of different materials, such as feathers and nutshells. He is building a boat on blocks that he will never put out to sea. He romances a succession of women in the boat, who finally leave him due to its cramped quarters and lack of a bathroom. ==
Sweet Thursday==