In 2003, three years after
the Caleb Goldman case, the events still haunt veteran American AMS agent James Taylor, who believes the ordeal hasn't ended. He returns to Europe, accompanied by a new rookie agent, Kate Green. While they gather intelligence at the fifth basement floor of the European headquarters of the AMS in
Italy (
London in the Japanese dub), a sudden
earthquake rocks the room while they talk, collapsing the basement walls and leaving the agents trapped. Several days later, as the two await a rescue team, James'
PDA goes off, and a group of undead are seen on the security cameras. Realizing that they are in danger, James has Kate gather all the weaponry they can find to defend themselves. Soon after, the two travel through the sewers to an information room, where they uncover a plot to fire nuclear missiles worldwide within 24 hours' time, facing the four-armed giant zombie, the
Justice, and a pair of mutant
tarantulas known as
The Lovers along the way. Taking the subway into zombie-infested streets from an underground shopping district, the agents narrowly avoid attacks by
The Empress, a double-ended chainsaw-wielding assassin, and the massive, obese, and nearly impervious
Temperance. James and Kate then learn that the late one-time CEO of the now-defunct DBR Corporation, Caleb Goldman, is responsible for the resurgence of undead. All of his messages and current plans were set in motion, even before his death. Upon reaching the surface, they find the city completely obliterated. Goldman sends them a PDA message indicating that the launch will occur in one hour. The agents head for the abandoned Goldman Building and upon arrival, a levitating humanoid named
The Star confronts them in the foyer. After the Star is defeated, the duo arrive in time to halt the missile launch, though it is revealed that Goldman's true intention is to revert humankind to its original state in order to prevent them from harming the planet further. As such, his final legacy,
The World, a cryokinetic insectoid humanoid, is released in the opening of "Pandora's Box" to fulfill its role as the successor to his original
Emperor project in 2000, having developed underground since his death. As the AMS agents fight it, The World continuously evolves to become larger and more powerful. Following The World's second defeat, James sets his PDA to self-destruct and, telling Kate not to give up hope, sacrifices himself to destroy The World in the ensuing explosion. A shaken and distraught Kate Green walks out of Caleb Goldman's premises.
Endings The game has four endings available depending on the player's performance result during the game, which at the end of either endings, the screen displays "The story continues in
The House of the Dead III". •
Standard Ending: A view of Caleb Goldman's computer playing a recording of him saying that "the human race hasn't been eliminated", instructing to "travel north" while musing that "hope is such a splendid thing" as he leaves the room. •
Bad Ending: The ending plays out the same as the standard ending, but the camera pans on Goldman's face, showing him changing into a zombie. •
"G" Ending: G appears outside the Goldman building, and states that the zombie crisis has not yet ended while telling James to rest in peace and he will assist the heroes to face what awaits. This ending has G in his
House of the Dead III appearance, suggesting to have taken place after his appearance in
The House of the Dead 4 Special and right before the events of
The House of The Dead III, as the game suggests the story continues there. •
Mystery Man Ending: The unnamed mysterious man previously seen in one of ''The House of the Dead III's'' endings sits in his study, declaring Caleb Goldman to be soft and that humans have no need of hope, before stating that the
true end shall soon begin and that there is more than one Pandora's Box. ==
The House of the Dead 4 Special==