The play had its world premiere at the American Theater Company in Chicago, Illinois, in November 2014, directed by PJ Paparelli.
Chris Jones, in his review for the
Chicago Tribune, wrote: "kind, warm, beautifully observed and deeply moving new play, a celebration of working-class familial imperfection and affection and a game-changing work for this gifted young playwright."
The Humans opened
Off-Broadway at the Laura Pels Theatre on September 30, 2015, in previews, and officially on October 25, 2015, in a limited run produced by the
Roundabout Theatre Company, with positive reviews, and ran until January 3, 2016. It transferred to
Broadway at the
Helen Hayes Theatre, opening on February 18, 2016, and closing on July 24, 2016. The play then transferred to the
Schoenfeld Theatre, re-opening on August 9, 2016. (The Helen Hayes had major renovations starting in August 2016.) The play closed its Broadway engagement on January 15, 2017. Directed by
Joe Mantello, the Off-Broadway cast featured Cassie Beck (Aimee),
Reed Birney (Erik),
Jayne Houdyshell (Deirdre), Lauren Klein (Fiona "Momo" Blake),
Arian Moayed (Richard), and
Sarah Steele (Brigid). While off-Broadway, the script won the 2016
Obie Awards for Karam's playwriting and Houdyshell's performance. The Off-Broadway cast moved to Broadway. The
Pittsburgh Public Theater staged
The Humans from November 9 to December 10, 2017, directed by Pamela Berlin; it was admiringly reviewed in the
Pittsburgh Post-Gazette.
Artists Repertory Theatre, located in Portland, Oregon, staged it from November 19 to December 17. The play embarked on a limited US national tour, starting in November 2017 at the Seattle Repertory Theatre. The tour cast featured
Richard Thomas as Erik,
Pamela Reed as Deirdre,
Daisy Eagan as Brigid, Lauren Klein as Momo, Therese Plaehn as Aimee and Luis Vega as Richard. The tour concluded on July 29, 2018, at the Ahmanson Theatre in Los Angeles. The play opened in London at the
Hampstead Theatre in September 2018 and closed on October 13, 2018. The Broadway cast reprise their roles, as does the director Mantello. Off the Dock Players produced the play in
Sandwich, New Hampshire. It opened on February 14, 2020, and closed on February 23. The production was directed by Nancy Blaine and starred Hank Offinger, Rebecca Cole, Ashley Bullard, Abe Garon, Marena Harris, and Lisa Thompson. "The Humans" had a Japanese premier in the New National Theater, Tokyo, between June 12–29, 2025. The Japanese translated production is directed by Yuko Kuwahara, known for her 2022 NNT production "Lobby Hero". The cast includes Shizuyo Yamazaki as Amy, Aoyama Misato as Brigid, Takeshi Hosokawa as Richard, Miyoko Inagawa as Momo, Masuko Wabunko as Deirdre, Mitsuru Hirata as Eric and Kishi Shusha as the Elderly Chinese woman. ==Critical response==