The show was unusual for occasionally addressing issues of race through a multiracial cast, unlike most American sitcoms in the 1990s. •
John Larroquette as John Hemingway •
Liz Torres as Mahalia Sanchez, John's secretary •
Gigi Rice as Carly Watkins, a high class escort and friend of Dexter's •
Daryl "Chill" Mitchell as Dexter Wilson, the depot's sandwich bar attendant and John's rival •
Chi McBride as Heavy Gene, a janitor at the depot •
Lenny Clarke as Officer Adam Hampton •
Elizabeth Berridge as Officer Eve Eggers •
Alison La Placa as Catherine Merrick (1994–1996) •
John F. O'Donohue as Max Dumas (1993–1994) •
Bill Morey as Oscar (1994–1996) •
Jazzmun as Pat (occasional, 1993–1995)
Recurring role •
David Crosby as Chester, John's
AA sponsor. •
Omri Katz as Tony Hemingway, John's son. Katz would be replaced in an unaired fourth-season episode with
Ryan Reynolds. •
Mayim Bialik as Rachel, John's daughter •
Ted McGinley as Karl Reese, Carly's boyfriend and future husband Over the course of its run, the show also featured
cameos from a number of celebrities.
Betty White,
Rue McClanahan and
Estelle Getty played themselves in a
Golden Girls/
Sunset Boulevard inspired episode. Fellow
Night Court actors
Harry Anderson,
Charles Robinson and
Marsha Warfield each appeared in an episode.
David Cassidy, who composed the theme song used for the show's first two seasons, fell down drunk in the bus station near the end of the second season.
June Lockhart and
Richard Mulligan appeared in separate episodes as John's parents.
Boyz II Men appeared in a 1994 episode that saw their tour bus break down at John's station.
Joe Pesci,
Richard S. "Kinky" Friedman,
Dennis Miller,
George Hamilton and
Ray Charles also appeared playing themselves in episodes. Other notable guest appearances included
Bobcat Goldthwait,
Matthew Perry,
Dick Martin,
Phil Hartman,
Rip Torn,
Jane Lynch,
Tim Daly,
Marion Ross,
Donna Mills,
Art LaFleur,
Joey Lawrence,
Molly Shannon,
Philip Baker Hall,
Len Lesser,
Deezer D,
Cheryl Tiegs,
Dinah Manoff and
Mila Kunis. ==Episodes==