Love & Other Drugs

In 1996, womanizer Jamie Randall is fired from a Pittsburgh electronics store for having sex with his manager's girlfriend. His wealthy brother Josh refers him for a job as a pharmaceutical sales representative. After attending a Pfizer training program, Jamie goes to work for them, attempting to get doctors to prescribe Zoloft. He is rebuffed, much to the dismay of his regional manager Bruce, who sees him as his ticket to the Chicago market. Bruce suggests Jamie get Dr. Stan Knight to prescribe Zoloft instead of Prozac, so other doctors will follow. He tries to gain access to Dr. Knight by flirting with his female employees, while secretly discarding the Prozac samples. Knight eventually allows Jamie to observe him examine one of his patients, Maggie Murdock, who has early onset Parkinson's disease. Taking an interest in Maggie, Jamie obtains her number from one of Knight's assistants, whom he previously seduced. Jamie and Maggie go on a date and agree that neither is interested in a serious relationship, so they start having casual sex. He is beaten up by top-selling Prozac rep, Trey Hannigan, who discovers that Jamie has been discarding his samples. Maggie reveals Trey is an ex-boyfriend, and she tells Jamie a rumor about Jamie's company developing a new drug to treat erectile dysfunction. Bruce confirms that Viagra is about to be marketed. Jamie starts selling Viagra, which is an instant success. He reveals that he wants a serious relationship, but Maggie breaks up with him. He confronts her while she helps senior citizens onto a bus bound for Canada to obtain cheap prescription drugs. They argue, but Jamie refuses to leave and waits for Maggie all night at a bus stop. Touched, she reciprocates feelings and they resume their relationship. Maggie accompanies Jamie to a medical conference, where she ends up at a Parkinson's support group across the street. She invites Jamie and he meets a man whose wife is in the final stages of the disease. Asked for his advice, the man tells him to leave Maggie before her symptoms inevitably worsen. After the convention, Maggie finally tells Jamie that she loves him. He begins researching Parkinson's and takes her to different specialists around the country for tests. Jamie becomes angry when they arrive at an appointment only to discover it has been rescheduled. Feeling he only wants to be with her if there is a hope for a cure, Maggie breaks up with him. Sometime later, Jamie and Josh are invited to a party by Knight, where Jamie takes Viagra and has a threesome with two women. He awakens with a rare side effect and goes to the hospital. Sometime later, he goes to a restaurant and encounters Maggie on a date. Bruce arrives and reveals Jamie has been promoted to the Chicago office. While packing, Jamie finds the videotape recorder with a video of himself and Maggie in happier times. He realizes he wants to be with her, but her boss tells him she has left for Canada for a prescription drug run. Jamie finds and tells Maggie he loves and needs her. She starts to cry, saying she will need him more. Jamie decides not to take the job in Chicago; instead, he attends University of Pittsburgh School of Medicine to be with her. == Cast ==

• Jake Gyllenhaal as Jamie Randall • Anne Hathaway as Maggie Murdock • Oliver Platt as Bruce Winston • Hank Azaria as Dr. Stan Knight • Josh Gad as Josh Randall • Gabriel Macht as Trey Hannigan • Judy Greer as Cindy • George Segal as Dr. James Randall • Jill Clayburgh as Nancy Randall • Nikki DeLoach as Christy • Katheryn Winnick as Lisa • Natalie Gold as Dr. Helen Randall • Michael Chernus as Jerry • Michael Buffer as Pfizer Convention MC • Bingo O'Malley as Sam • Jaimie Alexander as Carol (uncredited) The film was a posthumous release for Jill Clayburgh, who died on November 5, 2010. The film was dedicated to her memory. == Production ==

Background The fact that the film is based in part on Reidy's first-person memoir about his life as a Viagra salesman, and that the drug company Pfizer, along with other drug brand names, including Zoloft and Prozac, are repeatedly referred to, suggesting a conspicuous case of "product placement", director Edward Zwick has denied seeking approval for any of those names. Filming Principal photography began in the Pittsburgh, Pennsylvania region on September 21, 2009. The city was chosen for its atmosphere, rich medical history, the state's tax incentive program for film productions, and the area's experienced crews. Like Gyllenhaal, Hathaway had final cut over those scenes, using it to cut five seconds where she thought "the camera lingered a little bit". == Box office ==

Love & Other Drugs was released on November 24, 2010, and opened in 2,455 theaters in the United States, grossing $2,239,489 on its opening day and $9,739,161 in its opening weekend, ranking 6 with a per theater average of $3,967. On its second weekend, it remained 6 and grossed $5,652,810, averaging $2,300 per theater. By its third weekend it dropped down to 8 and made $2,981,509, averaging $1,331 per theater. The film had a domestic total gross of $32,367,005 against a production budget of $30 million. It fared much better overseas, where it grossed $70,453,003. == Reception ==

On Rotten Tomatoes gave the film holds an approval rating of 49% based on 170 reviews, with an average rating of 5.8/10. The site's critics consensus reads, "It's a pleasure to see Hollywood produce a romance this refreshingly adult, but Love and Other Drugs struggles to find a balance between its disparate plot elements." Metacritic gave the film a weighted average score of 55 out of 100, based on 38 critics, indicating "mixed or average" reviews. Audiences polled by CinemaScore gave the film an average grade of "B-" on an A+ to F scale. Roger Ebert of the Chicago Sun-Times gave it two and a half stars out of four, commenting that it "obtains a warm, lovable performance from Anne Hathaway and dimensions from Jake Gyllenhaal that grow from comedy to the serious". Kirk Honeycutt of The Hollywood Reporter gave the film a mixed review, writing: "The energy is far too great—manic even—at the beginning but calms down for a while to focus on the highly competitive but not always ethical arena of drug sales, then gets distracted by unusually bold sex scenes for a studio picture only to wander off into the cultural phenomenon of Viagra before the movie decides it's a romance after all and so concludes in a highly conventional final embrace." A negative review from the East Bay Express described it as "a spectacularly maudlin and repellent piece of work" where the two protagonists "try to outdo each other in the 'who cares' department with their alarmingly off-putting interpersonal communication", leading to "callous salesman jokes, callous sex jokes, even callous jokes about the homeless man who rescues drug samples from the Dumpster." An Associated Press reviewer found the film to be a "run-of-the-mill Hollywood love story". Betsy Sharkey of the Los Angeles Times gave the film a positive review, stating "Zwick is thankfully much more of a grown-up now in dealing with relationship entanglements. Somehow, between the epic and the intimate, between Hathaway and Gyllenhaal, love doesn't come easy, but with Love & Other Drugs, at least you don't have to wait." Mary Pols of Time stated, "Since American movies tend to be prudish about sex, especially having bona fide stars appear to do it onscreen, Love & Other Drugs' desire to thoroughly acquaint us with a topless Anne Hathaway and a bottomless Jake Gyllenhaal is a welcome change." James Berardinelli, film critic for ReelViews, praised the film and its story, giving it three and a half stars out of four. He wrote, "The first thing one notices about Love and Other Drugs is that it's an adult romance. So many current love stories are targeted at teenagers that it's rare to find one that sidesteps the numerous contrivances that permeate the genre." Accolades == References ==