• Arthur "Art" "Arturo" Keller: DEA agent, participant in the Operation Condor, obsessed with hunting down the Barreras, and other people responsible for killing his friend. Husband to Althea. Father of two children. • Adán Barrera: Nephew of Don Miguel Angel Barrera, brother of Raúl. Drug trafficker. Nicknamed Lord of the Skies. Based on
Benjamín Arellano Félix, although
Amado Carrillo Fuentes is "The Lord of the Skies." Barrera is also partly based on
Joaquin "El Chapo" Guzman. • Nora Hayden: Sex worker. Friend of Juan Parada. In love with Sean. Professional lover of Adán and Jimmy Piccone. • Sean Callan: Irish mobster and hitman for the Italian mafia. • Don Miguel Angel "Tío" Barrera: El Patrón, head of the drug trafficking organization. Uncle of Adán and Raúl. Based on
Miguel Ángel Félix Gallardo. • Juan Ocampo Parada: Cardinal, priest of the Barrera family. Nora's friend. Based on Cardinal
Juan Jesus Posadas Ocampo. • Güero Méndez: Drug trafficker, first an ally, then an enemy of the Barrera family. Husband of Pilar and father of her children. Based on
Héctor "Güero" Palma Salazar. • Sal Scachi: Former Colonel of the United States Army, now member of the Cimino crime family. • Jimmy Picone: Member of the Cimino crime family, acquaintance of Sean Callan and Sal Scachi. • Fabián "El Tiburon" Martinez: Main hitman of Raúl Barrera. Based on
David Barron Corona. • Raúl Barrera: Younger brother of Adán, co-leader of the Barrera cartel. Based on
Ramón Arellano Félix. • Gloria Barrera: Daughter of Adán and Lucia. • O-Bop: Friend of Sean Callan, Irish mobster. • Antonio Ramos: Friend of Arthur, member of the Mexican Police. • Ernie Hidalgo: Friend of Art Keller, member of the DEA. Based on
Enrique "Kiki" Camarena. • Cimino crime family: Based on the
Gambino crime family. ==Allusions to actual history, geography and current science==