Nicholas Flamel – The title character, an alchemyst. Along with his wife, Perenelle, he has lived for nearly 700 years searching for Josh and Sophie Newman, the Gold and Silver twins of legend, who can save the Shadowrealm of
Earth from the mad
Dr. John Dee and the Dark Elders who seek to destroy it. Flamel is a legend who built his fortune through alchemy, which he uses to amazing effect to combat the horrors Dee sends after the twins and himself. Despite good intentions, however, he is not without flaws, like being selfish and not learning from his mistakes and seeks glory for training Josh and Sophie.
Josh Newman – The Gold twin of legend. Awakened by
Mars Ultor, Josh is a lover of history and a natural strategist. However, he is suspicious of Nicholas Flamel, due to his not telling them of the previous twins' demise, a fact that causes Josh to temporarily shift alliances, though he remains cautious of Dee. Eventually, he sides with Flamel.
Sophie Newman – The Silver twin of legend. Awakened by
Hekate (the Goddess of Three Faces), and later trained by
The Witch of Endor, who infuses her memories and experiences into her. Sophie is protective of Josh and more patient, though she is also horrified by the twins' fates. She decides to side with the Flamels to save Earth, but seeks out her brother eventually.
Dr. John Dee – The main antagonist. An English magician and
necromancer who formerly advised
Queen Elizabeth I, he seeks to bring back to Earth the Dark Elders, who wish to destroy and rebuild it. However, after he is declared
utlaga, or outlaw, for failing them, he decides to use the four swords of power –
Excalibur,
Clarent,
Joyeuse and
Durendal – to go back in time to Danu Talis and destroy them, convincing Josh to join his side with the promise of a renewed Earth. Eventually he sides with the Flamels but by then it is too late.
Perenelle Flamel – The wife of Nicholas, and a powerful sorceress. Being the seventh daughter of a seventh daughter, she can contact ghosts and has a long-standing feud with
Machiavelli. Many have suggested, correctly, that she is much more powerful than Nicholas, as she has proven as she tries to save San Francisco from the horrors on nearby
Alcatraz.
Niccolò Machiavelli – A renowned Italian philosopher and eventual warlock, or
waerloga, who is tasked with releasing an army from Alcatraz after helping Dee in Paris. He and Josh have an understanding, as they are both human in spirit, a trait which he later shares with
Billy the Kid. This trait causes Machiavelli to re-evaluate his opinions of the Dark Elders and reform and break his oaths to them, choosing not to release the monsters on the humani.
Scathach - The Celtic goddess of the war. She has a grey aura. She is an Elder of the 2nd generation and a vegetarian vampire. She is approximately 10000 years old but looks 17 and claims to be 2000. She will accompany the alchemist and the twins in their adventures but will be taken by Dagon in the Seine. It is the great friend of Joan of Arc, that she educated. She was the creator of most of the martial arts and formed the biggest Heroes of the History. To have helped the human beings during the Fall of Danu Talis, she was rejected by her family before saving their life a few years later. She speaks few his parents and her brother. She has a twin sister (Aifé) but they would have long ago become muddled because of a boy, they do not speak to each other any more. Scathach is also called "the Shadow", the "Goddess Warrior", "the King Maker", "the Warrior Maiden" "the Daemon Slayer" and Scatty. Her grandmother is the Witch of Endor, her presumed grandfather being Mars Ultor. ==Titles' significance==