•
Paul Rudd as Jeff Reigert, Gretchen's husband and a man who hosts the stories and has an affair, but ends up reconciling with his wife. •
Winona Ryder as Kelly LaFonda, Stephen's ex-fiancée who steals a puppet. •
Famke Janssen as Gretchen Reigert, Jeff's wife who reconciles with him in the end. •
Jessica Alba as Liz Anne Blazer, Jeff's young mistress who he has an affair with, but ends up dumping him. •
Adam Brody as Stephen Montgomery, Kelly's ex-fiancée who is embedded in the ground as the result of a skydive accident. •
Justin Theroux as
Jesus H. Christ, the son of god who is portrayed as a seductive Mexican. •
Oliver Platt as Marc Jacobson, an impersonator who becomes the adopted dad of 2 black teens. •
Liev Schreiber as Ray Johnson, a police detective who ends up competing with his neighbor by purchasing excessive CAT-Scan machines. •
Gretchen Mol as Gloria Jennings, a librarian, Noah's mother and Oliver's wife who has a fling with the Spanish Jesus, •
Rob Corddry as Duane Rosenblum, a prisoner in the jail Glenn is sent to and wishes to have Glenn's raper as his own. •
Michael Ziegfeld as Harlan Swallow / Gary, a ventriloquist whose puppet, Gary, is stolen by Kelly and is now a drug-addicted hobo. •
Ken Marino as
Dr. Glenn Richie, a joke-loving doctor convicted of murder that he insists was "a goof". •
Janeane Garofalo as Beth, an employee at the nuclear power plant who panics when minors have been exposed to radiation. •
Mather Zickel as Louis La Fonda, a news reporter who publishes Stephen's situation from the skydiving incident and becomes Kelly's new husband. •
Kerri Kenney-Silver as Bernice Jaffe, a single mother to 2 African-American twin teens who welcomes Marc as her son's new dad. •
A.D. Miles as Oliver Jennings, Noah's father and Gloria's husband who hosts a nude party on a Sunday •
Michael Showalter as Police Lieutenant Flarn Bairn, a cop Swallow reports the theft of Gary too. •
David Wain as Abe Grossman, a reporter who interviews Stephen after his accident. •
Thomas Lennon as Scotty Pale, one of Paul's friends. •
Bobby Cannavale as Marty, Oliver's friend who joins him at his naked party. •
Ron Silver as Fielding Barnes, an agent who makes Stephen a star, but ends up deserting him. •
Joe Lo Truglio as Paul, Ray's neighbor who battles him through purchasing lots of CAT-Scan machines. •
Robert Ben Garant as Bob, the Foreman for the jury at Dr. Ritchie's trial. •
Jason Sudeikis as Tony Contiella, the widower husband of Dr. Ritchie's murdered victim who was a temp for Gloria when she took a vacation to Mexico. •
Kevin Allison as Stanley •
Rashida Jones as Rebecca, a hostess who introduces Swallow and Gary. •
Jon Hamm as Charles, a flight instructor to Stephen •
Tommy Nelson as Noah Jennings, Gloria and Oliver's son. •
Michael Ian Black as Prison Guard • Cedric Sanders as Greg Jaffe •
H. Jon Benjamin voices The Lying Rhino, a deceptive animated rhino whose deception caused him to be helpless in halting a horrendous orgy caused by sexually transmitted
Dachshunds. He is portrayed by
Peter Salett in the live-action part of the movie. • John Tormey as Junkie Jerry Park •
Jason Antoon as Salazar 'Fred' McBairn ==Reception==