Three days after
Hank's disappearance, the O.S.I. is distracted with a low-level Guild villain attacking one of their labs with technology supplied by the mysterious new villain organization ARCH. The Council of Thirteen assigns
Dr. Mrs. The Monarch and
Red Death to investigate.
The Monarch, after his Guild initiation reveals via DNA test that they are seemingly related, is forbidden from attacking
Dr. Venture until their relationship is confirmed. Meanwhile, Dr. Venture struggles with perfecting VenTech's newest invention, the "HelperPod"
virtual assistant, due to a bug that makes it levitate while playing music. Driven by guilt over sleeping with Hank's girlfriend,
Dean goes to
Orpheus for help, and they set off, with
Jefferson, to find him. Acting on advice from his imaginings of various characters he enjoys playing (The Detective, The Bat, Russian Guyovich, and Enrico Matassa), Hank returns to his old family home at the Venture compound to rediscover himself. The Monarch is approached by his ex-girlfriend and ARCH's invisible leader Mantilla, who promises to let him arch Dr. Venture again if he joins them. Upon his arrival at the abandoned Venture compound, Hank encounters his old friend and O.S.I. cadet Dermott, who found a picture of "Bobbi St. Simone" signed to Dr. Venture amongst his collection of stolen Venture memorabilia. During a detour, Jefferson is attacked by blaculas in
Chicago, where Dean is seemingly bitten by one and tries to hide it. Dr. Mrs. The Monarch is framed as ARCH's leader and blacklisted by the Guild, but Red Death helps her escape. The Monarch and
21 are abandoned by ARCH upon breaking in to VenTech Tower, while Mantilla uses 21's phone to hack into the HelperPods and use their levitating bug to uproot the tower, sending them into orbit. Hank arrives at Bobbi's animal sanctuary, who explains that she had a brief tryst with Jonas after he gave her invisibility powers for a movie. She was later recruited by the O.S.I. as a Guild mole, but fell in love with the Guild's leader Force Majeure and had a daughter, Mantilla. The two were later forced to flee and went into hiding after The Sovereign killed Majeure for Guild leadership. Hank, overwhelmed by his head injury, falls back into
purgatory.
Billy and
Pete advise Rusty to individually destroy the HelperPods to slowly lower the tower back to earth. He,
Hatred, The Monarch, and 21 are nearly killed by their gravitational field when they try, forcing them to hide in the air ducts. Dr. Mrs. The Monarch breaks into Mantilla's apartment, where she is waiting for her and explains that she wants to run ARCH with her out of admiration. She mentions that Dr. Venture had transferred her mother's invisibility to her in exchange for her
eggs (implying that she is technically Hank and Dean's biological mother) and that she is the rightful heir to the Guild. She turns off the HelperPods in exchange for Guild immunity, causing the tower to start falling at a lethal speed. Orpheus comes to purgatory to rescue Hank, who is moved by the fact that Dean is the one who led his rescue. Dean accidentally transports himself to purgatory and is attacked by the physical manifestations of Hank's characters. Orpheus pulls them both out and Hank finally forgives his brother. Hatred discovers the Ventronic mech inside the tower as they reenter the atmosphere, and the team devises a plan to slow the building's descent. They marginally slow the tower using Ventronic, though The Monarch accidentally ejects his part of the robot in the process. Aided by Hunter Gathers and the O.S.I.'s mothership, Ventronic safely lowers the tower into the ruins of the compound, while The Monarch is impaled by the fallen statue of Jonas after leaving the arm. Dean nervously reveals his bite to Jefferson, who explains that he merely injured himself on Jefferson's tooth necklace when he tackled Dean to safety. Ben arrives on the scene and saves The Monarch's life by using Dr. Venture's blood for a
transfusion, and Ben reveals that they are not related: Monarch—-like Doctor Venture—-is a clone of the original Rusty Venture, infused with minor traces of baboon DNA (to combat premature baldness) which caused his extreme aggression. The Fitzcarraldo family adopted Monarch as they could not have children of their own. Ben gives Hank a custom
GMT Master, given to him by Jonas before Dr. Venture was born. Ben makes note of the engraving on the back, Elige Tua (choose your family), telling Hank that "blood doesn't make a family, love does", while Dr. Venture promises Dean that whoever "gave birth to him" loves him. A weakened Monarch declares his determination to hate Dr. Venture and leaves in triumph. Later, in a
flashback montage, a young Dr. Venture reveals Hank and Dean to H.E.L.P.eR., who are growing in an artificial
womb attached to his chest. ==Cast==