The two main characters of the show are Killface, who is a naked, bone-white, red-eyed, earless, talon-toed, spur-heeled, , , hairless, muscular humanoid
supervillain focused on destroying Earth with his invention, the Annihilatrix; and billionaire tycoon Xander Crews, who fights crime under the superhero alias Awesome X. Both Killface and Xander are voiced by co-creator Adam Reed. The two have an ever-shifting relationship, changing from enemies to unwilling allies on many occasions. Other major characters include Killface's son Simon – voiced by
Christian Danley – an overweight, blond-haired, pale-skinned, sexually confused, teenaged
Hannah Montana fan, who wears sweater vests and exhibits adolescent rebellion by muttering and breaking cereal bowls; reporter Grace Ryan, former girlfriend of Xander Crews turned into Antagone, a toxic, radioactive ant-powered villainess; Sinn – voiced by
Kelly Jenrette – later known as Hooper, originally Killface's
sidekick and later his enemy; and the Xtacles, Awesome X's team of easily distracted and remarkably inept, rocket-booted troops. ==Setting==