Theodora Megale Komnene, , was Empress of Trebizond from 1284 to 1285. All Michael Panaretos tells us about her is that she was a daughter of Emperor Manuel I of Trebizond by Rusudan, a Georgian princess. Although some consider her Manuel's second wife, Michel Kuršanskis has argued that Rusudan may have been simply his mistress. Kuršanskis also notes that the evidence is insufficient to determine if Theodora was identical with one of the princesses of Trebizond mentioned in the Chronicle of Bishop Stephanos who married a noble or the king of Georgia, or if she had been a nun — much as Anna Anachoutlou was before her usurpation in the following century.