Early life and service under Theodore II (), George Mouzalon's friend and patron The
Mouzalon family is first attested in the 11th century, but produced few notable members until the mid-13th century, with exception of
Nicholas IV Mouzalon,
Patriarch of Constantinople in 1147–1151. George Mouzalon was born at
Adramyttium on the western
Anatolian coast in . His family was considered as low-born, but he and his brothers became the childhood friends of the future
Theodore II Laskaris, being raised with him in the palace as his
paidopouloi (παιδόπουλοι, "
pages"). It is assumed that they were also educated along with Theodore, sharing his classes under the scholar
Nikephoros Blemmydes. There were also at least two sisters, one of whom was later married to a member of the
Hagiotheodorites family. According to the contemporary chroniclers, the emperor loved George "above all others"; in some letters he calls him "son" and "brother". During Theodore's reign, George was the Emperor's senior minister and his most trusted advisor. Little is known, however, about his personal involvement in the governance of the state, except for his participation in the council convened to discuss the proper reaction to the invasion of Nicaea's
Macedonian holdings by the
Bulgarians after the death of Theodore's father,
John III Doukas Vatatzes. George Mouzalon supported the majority opinion that Theodore himself should campaign against the invaders. During Theodore's absence on campaign in 1255, George was left behind as regent of the state. The aristocrats' hostility was further intensified when the emperor gave his low-born favourites noble brides: George Mouzalon wedded
Theodora Kantakouzene, a niece of Michael Palaiologos, and Andronikos married a daughter of the former
protovestiarios Alexios Raoul. Immediately after his death, George Mouzalon, aware of his vulnerability and his complete lack of support, called an assembly of the leading nobles, officials, and military commanders. He offered to resign from his post in favour of any person that the assembly chose, but the dignitaries, led by Michael Palaiologos, dissuaded him and encouraged him to stay on and even accepted to take an oath of loyalty to him as well as to the young emperor. It was a sham, as a conspiracy by the leading aristocratic families was well under way to depose him, in which Palaiologos apparently played a covert but leading role. Ostensibly still the guardian and co-emperor of John IV, after the recapture of
Constantinople in 1261 he sidelined and imprisoned John, being crowned sole emperor at the
Hagia Sophia and founding the
Palaiologan dynasty, the last ruling house of Byzantium. == Treatment by historians ==