Thessalonike's date of birth is unknown. While there is a consensus that her name commemorates her father's victory in
Thessaly (it is a composite of "Thessaly" and "nike," the Greek word for "victory"), it is unclear which victory it specifically references. Some historians cite her birth as being as early as 353 or 352 BC, but 346/5 may be more accurate.
Nicesipolis did not live long after Thessalonike's birth. According to
Stephanus of Byzantium, Philip gave the baby to a woman named Nice to raise.
Olympias, who may have been a friend of Nicesipolis, may have taken Thessalonike to be raised as her own daughter following her mother's death. Little is known about Thessalonike's early life. Philip II did not arrange Thessalonike's marriage, as he did for her sisters, likely due to her youth at the time of his death. The fall of Pydna and the execution of her stepmother threw her into the power of Cassander, who embraced the opportunity to connect himself with the
Argead dynasty by marrying her, possibly by force. Thessalonike became queen of Macedon and the mother of three sons,
Philip,
Antipater, and
Alexander. After the death of Cassander, Thessalonike appears to have at first retained much influence over her sons in 295 BC. Her son Philip succeeded his father, but died shortly after taking the throne. Shortly after Philip's death, Antipater murdered his mother. The reason for this is unclear, but most sources say that it was due to jealousy.
Justin claimed that Thessalonike demanded that Antipater, the next eldest son, share the rule with Alexander. The decision to kill his mother, rather than Alexander, may imply that Thessalonike was acting as regent for Alexander, as many of her female relatives had done previously. ==City of Thessaloniki==