He married Elizabeth Meverell (died 1651), daughter and heiress of Robert Meverell of
Ilam, Staffordshire, and of
Throwley Old Hall, Staffordshire (died 5 February 1627/1628) and Elizabeth Fleming, both buried at
Blore, Staffordshire, the daughter of Sir
Thomas Fleming,
Lord Chief Justice of the King's Bench, and had three children: •
Wingfield Cromwell, 2nd Earl of Ardglass (12 September 1624 – 3 October 1668) •
Vere Essex Cromwell, 4th Earl of Ardglass (2 October 1625 – 26 November 1687) • Mary Cromwell (died 8 April 1676), married as his first wife William FitzHerbert, of
Tissington, Derbyshire (1624/1629 – 24 June 1697), who married secondly Anne Breton, widow of John Parker, of London, and daughter of Richard Breton, of
Elmesthorpe, Leicestershire, without any male issue. He and his wife both died in 1653 and were buried at
St Peter's Church,
Tickencote,
Rutland, and his last
will, dated 26 March 1653, was
probated in 1661. ==Arms==