While Oxley has been conducting research in
motor systems since 2003, he is said to have conceived the idea for the Stentrode™ in 2007 and he led the original team at the University of Melbourne that created the technology.
Stentrode is the first motor neuroprosthesis, a form of brain-computer interface implanted via the patient's blood vessels. Oxley's team in Australia was the only non-US-based group funded by DARPA as part of the
Reliable Neural-Interface Technology (RE-NET) program and led by Professor Jack Judy. Dr. Oxley announced in a 2018 TEDxSydney Talk that the company, Synchron, would initiate clinical trials of the Stentrode device with the goal of assisting paralyzed patients to regain independence. Just two years later, Oxley and Synchron published a first-in-human study on the device in the
Journal of NeuroInterventional Surgery. The study showed the ability of two Australians with
ALS to email, text, shop, and bank online using the Stentrode Device, and was conducted at Royal Melbourne Hospital. Earlier in 2020, the company had announced that it received Breakthrough Device status from the US Food and Drug Administration (
FDA) for the Stentrode. Oxley's work has been published in major journals including Nature Biotechnology and New England Journal of Medicine, and he is the founder of three start-up companies: SmartStent (which was acquired by Synchron, Inc.), VascuLab and Synchron. == COVID-19 research ==