Salisbury was the elder son of
Katheryn of Berain and her first husband, Sir John Salusbury, and was the heir to the
Lleweni Estate. Salisbury's father died in 1566 shortly after the birth of his second son
Sir John Salusbury. He married Margaret Wynn (daughter of Katheryn's third husband, Maurice Wynn) in 1575 through a
child marriage. Salisbury did not assent to the marriage, and the couple were estranged for a period prior to the birth of their daughter Margaret. Salisbury's daughter Margaret would eventually inherit Berain, whereas Lleweni went to Thomas's younger brother,
Sir John Salusbury. ==Babington Plot==