Wharton was the only son of John Wharton (d. 10 June 1629) by his wife Elizabeth, daughter of Roger Hodson (d. 10 March 1646) of
Fountains Abbey, and was born at
Winston-on-Tees,
county Durham, on 31 August 1614. His father died when he was 15 and he suffered from a severe febrile illness when he was 19. He was admitted as a
sizar at
Pembroke College, Cambridge, on 4 July 1638, and matriculated two days later. He migrated to
Trinity College, Oxford in 1642, where he acted for some time as tutor to John Scrope, natural son of
Emanuel Scrope, 1st Earl of Sunderland. Later in 1642 he went to
Bolton, where he remained three years studying; he also became and then, having decided upon his future profession, removed to London and studied medicine under
John Bathurst In 1646 he returned to Oxford, and obtained his M.D. on 7 May 1647. He was entered as a candidate of the
College of Physicians on 25 January 1648, chosen fellow on 23 December 1650, incorporated at Cambridge on his doctor's degree in 1652. He held the post of censor of the Royal College of Physicians in 1658, 1661, 1666, and 1673. He obtained the appointment of physician to
St Thomas's Hospital on 20 November 1659, and retained it till his death in 1673. Wharton was one of the very few physicians who remained at his post in London during the whole of the outbreak of the
plague of 1665. His services were recognised by a promise of the first vacant appointment of physician in ordinary to the king. When, however, a vacancy occurred and he applied for the fulfilment of the promise, he was put off with a grant of honourable augmentation to his paternal arms, for which he had to pay
Sir William Dugdale. Wharton died at his house in
Aldersgate Street on 15 November 1673, and was buried on the 20th in the church of
St Michael Bassishaw in Basinghall Street. He married Jane, daughter of William Ashbridge of London, by whom he had three sons: Thomas, father of George Wharton (both physicians; George married Anna Maria, daughter of
William Petty), Charles, and William; the last two died young. His wife predeceased him on 20 July 1669, and was buried at St Michael Bassishaw on the 23rd. A memorial in the church was moved in 1897. ==Work==