Greene was considered one of the top prospects for the
2019 Major League Baseball draft. Greene made his professional debut on June 24, 2019, for the rookie-level
Gulf Coast League Tigers. In July, he was promoted to the
Connecticut Tigers of the
Low–A New York-Penn League, and in August, he earned a promotion to the
West Michigan Whitecaps of the
Single–A Midwest League. Over 57 games between the three clubs, he slashed .271/.347/.403 with five home runs and 28 RBIs. Greene did not play in a game in 2020 due to the cancellation of the minor league season because of the
COVID-19 pandemic. Greene began the 2021 season with the
Erie SeaWolves of the
Double-A Northeast. In June, he was selected to represent the Tigers in the
All-Star Futures Game alongside
Spencer Torkelson. In August, he was promoted to the
Toledo Mud Hens of the
Triple-A East. Over 124 games between the two clubs, Greene slashed .301/.387/.534 with 24 home runs, 84 RBIs, 16 stolen bases, 25 doubles, and eight triples. He was named the 4th best prospect in baseball in
Baseball America annual Top 100 list for 2022. The Tigers planned to include Greene on their
Opening Day roster for the 2022 season, but he broke his right foot and missed the start of the season. On June 18, 2022, the Tigers purchased Greene's contract, adding him to the active roster, and he made his Major League debut that afternoon. In his first at-bat, he hit a single. On July 2, 2022, Greene hit a
walk-off home run off of
Joel Payamps of the
Kansas City Royals for his first career MLB home run. He became the first Tigers player since
Lou Whitaker in 1978 to accomplish this feat. Greene was named the 2022 Detroit Tigers Rookie of the Year by the Detroit Sports Media Association and Tiger of the Year by the Detroit Chapter of the
Baseball Writers' Association of America. In 2023, Greene played in 99 games for Detroit, hitting .288/.349/.447 with 11 home runs, 37 RBI, and 7 stolen bases. On September 2, 2023, Greene was placed on the injured list with right elbow inflammation. On September 19, it was announced that he would undergo surgery to repair his non–throwing elbow. The next day, the Tigers announced that Greene had undergone
Tommy John surgery, and would likely be ready by the start of the 2024 season. On July 7, 2024, Greene was selected to represent the Tigers in the
2024 All-Star Game on July 16, along with teammate
Tarik Skubal. At the time of his selection, Greene was hitting .258 with 17 home runs and 45 RBI. He ranked fourth among AL outfielders with an .863 OPS, and third among AL left fielders with a plus-8 Defensive Runs Saved rating. He entered the All-Star game as a reserve in left field, and went 0-for-2 at the plate. For the season, Greene hit .262/.348/.479 with 24 home runs and 74 RBIs in 137 games, as he helped the Tigers return to the playoffs after a 10-year drought. On May 2, 2025, Greene became the first player in MLB history to hit 2 home runs in the 9th inning of a game. He was named AL Player of the Week for April 28-May 4 after hitting .464 with 13 hits, 4 home runs, 8 RBI and a 1.393 OPS. He had at least one hit in all seven games during the week, with three multi-hit games. On June 13, Greene went 2-for-4 with a home run and 4 RBIs against the
Cincinnati Reds as he reached the 200-RBI mark for his career. Greene becomes the first player in Tigers franchise history to drive in 200 runs before turning age 25 since
Travis Fryman in 1992. On July 2, Greene was voted in as a starting outfielder for the
2025 All-Star Game. It is his second consecutive All-Star selection, and first as a starter. At the All-Star break, Greene was hitting .284 with 24 home runs (equaling his 2024 season total) and 78 RBI. On August 26, 2025, Greene hit a grand slam homer at
Sutter Health Park (the temporary
Sacramento, CA home of the Athletics) that traveled an estimated 471 feet (143.6 meters) over the large "batter's eye" wall in center field. It was the longest home run by a Tiger in the Statcast era (since 2015) and the fourth longest homer in the majors to date in 2025. Greene finished the 2025 regular season batting .258 with career highs in home runs (36) and RBI (111), becoming the first Tiger player to reach 35 home runs and 110 RBI since
Miguel Cabrera in 2013. He also had the dubious distinction of becoming the 17th major league player and first Tiger to strike out at least 200 times in a season (201). His strikeout total surpassed the previous team high of 182, set by
Cecil Fielder in 1990. On January 6, 2026, the Tigers and Greene agreed on a one-year, $5 million contract, avoiding arbitration. ==References==