The TNFAIP3 locus is implicated as a positively associated factor in
rheumatoid arthritis (RA). The rs5029937 (T) and the rs6920220 (A)
SNPs increase risk of RA by 20 to 40% respectively. A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful.
Other diseases An association with infantile onset intractable inflammatory bowel disease has also been reported. ==See also==