Tobacco water, tobacco juice, tobacco dust juice, or tobacco lime is a traditional organic insecticide used in domestic gardening. In The English Physician Enlarged of 1681, and later editions, Nicholas Culpeper recommended tobacco juice to kill lice on children's heads, referencing it as an insecticide poison, as well as a general cure-all. Farmers have been using nicotine sulfate insecticide since the early 19th century.