"Todo de Ti" became Alejandro's breakthrough solo song and his biggest hit in his career to date. The track debuted at number nine on the US
Billboard Hot Latin Songs chart on June 5, 2021, with a first-week tally of 500 downloads sold, 3.8 million streams, and 4 million radio impressions. Thus, it became Alejandro's first solo top 10 hit on the chart, and his fifth overall. It subsequently peaked at number two on the chart on September 11, 2021, being held off the top spot by "
Pepas" (2021) by
Farruko, while giving Alejandro his first top two track. "Todo de Ti" has since become Alejandro's longest-charting hit on the Hot Latin Songs, spending 43 weeks on the chart. The song also reached number one on the US
Latin Digital Song Sales,
Latin Airplay, "Todo de Ti" debuted at number 66 on the US
Billboard Hot 100 on the chart issue dated June 12, 2021, and peaked at number 32 in its fifth week, becoming Alejandro's second entry on the chart and his highest peak in his career, surpassing "
Baila Conmigo", which peaked at number 74 on February 13, 2021. "Todo de Ti" was certified
sextuple platinum (
Latin) by the
Recording Industry Association of America (RIAA), for track-equivalent sales of over 360,000 units in the United States. In Canada, the song peaked at number 91 on
Billboards
Canadian Hot 100 on the chart issue dated July 10, 2021, giving Alejandro his second entry, and was certified gold by the
Music Canada, for track-equivalent sales of over 40,000 units in the country. Besides North America, the track hit the charts in several European countries, including France and Italy. It was certified gold by the
Syndicat National de l'Édition Phonographique (SNEP), for track-equivalent sales of over 100,000 units in the former, and platinum by the
Federazione Industria Musicale Italiana (FIMI), for track-equivalent sales of over 70,000 units in the latter. In Spain's official weekly chart, the song debuted at number one on May 30, 2021, and spent a total of nine consecutive weeks at this position, becoming his second number-one hit in the country, following "
La Nota" (2020). "Todo de Ti" was later certified 11× platinum by the
Productores de Música de España (PROMUSICAE), for track-equivalent sales of over 660,000 units in the country, and finished 2021 as the biggest hit on the country's year-end chart. In Latin America, the song experienced a huge commercial success. It peaked at number one in Argentina, Bolivia, Chile, Colombia, Costa Rica, Dominican Republic, Ecuador, El Salvador, Guatemala, Honduras, Latin America, Mexico, Nicaragua, Panama, Paraguay, Peru, Puerto Rico, and Uruguay. The track was subsequently ranked as the best-performing song of 2021 in Latin America. In Mexico, the song was certified diamond + 4× platinum by the
Asociación Mexicana de Productores de Fonogramas y Videogramas (AMPROFON), for track-equivalent sales of over 1,260,000 units. It was also certified platinum by
Pro-Música Brasil for track-equivalent sales of over 40,000 units in Brazil. == Music video ==