Woodeshick was selected by the Buffalo Bills in the fourth round of the
1963 American Football League (AFL) draft (28th overall), and by the Philadelphia Eagles in the eighth round of the
1963 NFL draft (102nd overall). He signed with both teams, resulting in a legal dispute. It was determined that the Bills contract was invalid because he signed before the AFL draft had occurred and therefore the Bills had no signing rights at the time. Woodeshick thought that this additional focus on him, and the fact that he outran Eagles star
Timmy Brown in the 40-yard dash, gave him an increased opportunity to make the Eagles team. The Eagles had a very poor team in
1968. They began the season 0–11 and finished 2–12, the team owner was in bankruptcy, and a notoriously difficult fan base was very hostile toward the team. Woodeshick was a rare bright spot on the team. He rushed for 947 yards at 4.4 yards per carry, and had 36 receptions for another 328 yards. He was selected to the Pro Bowl and was named second-team All-Pro by the Associated Press (AP). He was third in the league in rushing behind
Leroy Kelly and
Ken Willard. Woodeshick regretted he was not able to rush for 1,000 yards that year. In the final game of the season, he needed another 133 yards against the
Minnesota Vikings to reach 1,000 yards. By the third quarter he had gained 80 yards and needed only 53 more. Woodeshick was second-team All-Pro again in 1969 (per the AP,
United Press International, and
Pro Football Weekly), rushing for 831 yards at 4.5 yards per carry, with 22 receptions. In the early 1970s he was hampered by knee injuries. He said at the time of being cut:The St. Louis Cardinals picked him up in 1972, but he played in only 4 games with 5 rushing attempts. He retired from the game that year. Sports Illustrated deemed him the best Eagle to wear number 37. ==NFL career statistics==