While studying at the University of Lagos, Tedela was cast in his screen debut as Julian in the family TV Series
Edge of Paradise. He stopped acting for a while to concentrate on his studies; while in school and shortly after graduation, Tedela worked as an on-air personality at
UNILAG FM. He made a return to star as Lala in his first leading role in the feature film
A Mile from Home, gaining prominence through the role. At one time, Tedela was a news anchor at the
NTA. He acted in several notable stage performances. In 2015, Tedela starred in ''A Soldier's Story
and Out of Luck''. Tedela's role as
metrosexual Kyle Stevens-Adedoyin in the 2016 comedy film ''Suru L'ere'' earned him many rave reviews. Tedela starred in these well-received films in 2017: the epic
King Invincible, the comedy-crime/heist film
Ojukokoro and the action-drama
Slow Country. He made his producing debut with the drama thriller film
What Lies Within. In 2018, Tedela appeared in the crime film,
Knock Out Blessing. In 2019, he starred as researcher Dr Dauda in
The Lost Okoroshi which had its world premiere at the
2019 Toronto International Film Festival and received mostly positive reviews. He also began work on his one-man play
Whumanizer. Tedela also starred in the gripping drama film,
The Ghost and the
House of Truth. In 2020, Tedela was cast in
Netflix's first Nigerian original series helmed by award-winning director
Akin Omotoso. In 2022, he portrayed Dr Adeboye/The Good Doctor in the Netflix original series
Blood Sisters. Tedela received acclaim for his work in the award winning film
All the Colours of the World Are Between Black and White which won several awards including the
Berlinale Teddy Award. Of his performance, Michael Joseph Jenner wrote: "with his silent moments of reflection being beautifully portrayed by Tope Tedela, whose performance is very quiet and internal, but simmers with an understated complexity that only grows as the film continues to explore his voyage of self-examination, portraying his efforts to feel less lost and isolated in a rapidly changing world, although one in which his identity is still a source of considerable contention amongst those who are more aligned with traditional values". In 2025, Tedela played Nurse Chinedu in the Netflix series
Baby Farm. ==Other work==