He conducted research in nephrology, hypertension and internal medicine. His most notable research is salt-induced hypertension and the role of the kidney. His work spans basic to clinical research. His hypothesis was validated by a double-blind
clinical trial. In 1976 he was a visiting fellow at
NIH. From 1978 to 1988 he lectured at
Tsukuba University and
The University of Tokyo, Faculty of Medicine, Dept of Nephrology and Endocrinology and became an associate professor at the latter in 1989. In 1995 he became a full professor and the chair in medicine. He moved to the Research Center for Advanced of Science & Technology in 2012 and was the
principal investigator of CREST-
JST. In 2012 he became Professor emeritus. == Recognition ==