In 2017, she was a cast member at
The Second City in
Chicago, where she had previously been a recipient of the Second City's Bob Curry Fellowship. During 2017–2020, she appeared in guest roles in several TV series, including
Easy,
Hot Date, ''
Sherman's Showcase, and Space Force. In 2021, she was a staff writer for the second season of Work in Progress, and co-wrote and appeared in one episode. She also appeared in the Chicago-set horror film Candyman and an episode of the comedy series South Side''. In 2021, Tran was cast as a series regular in the
Hulu sitcom How I Met Your Father, a spin-off of the series
How I Met Your Mother. She plays Ellen, who moves to New York from a small farming town in Iowa after divorcing her wife. The series aired for two seasons from 2022 to 2023. In 2024, she appeared in a recurring role in the
Peacock comedy series
Mr. Throwback. Tran is a regular contributor to the feminist podcast
Hysteria, hosted on
Crooked Media. In 2023, she co-hosted the podcast
In These Cleats with
Angel City FC defender
Paige Nielsen, which launched during the
2023 FIFA Women's World Cup and covered women's soccer. Since 2024, she has co-hosted the
queer and
women's sports-focused podcast
Jockular with
E. R. Fightmaster and
Katie Kershaw. == Personal life ==