Clonally transmissible cancer

Transmissible cancers require a specific combination of related circumstances to occur. These conditions involve both the host species and the tumors being transferred. These typically include low genetic diversity among individuals, an effective physical and environmental transport system, and a high enough dose of infective material. The cancers that reproduce faster in larger quantities with different means of reproduction tend to be favored for transmission if host conditions are met. Transmissible cancers follow the general pattern of cancer spread, starting with the growth of primary cancer cells at tumor sites followed by invasion of surrounding tissue and subsequent spread throughout the organism. The main hurdles for surviving cells of a successful spread to a new host are histocompatibility barriers. The cancers have to bypass the self recognition system, survive the difference in nutrients and induce the correct response in the new hosts to begin the cycle anew. Transmissible cancers behave as true parasites, relying primarily on transport systems like direct contact, environmental transport and vectors, rather than hematogenous and lymphatic carriers to spread between organisms. The amount of shedded cancer cells from initial host has to be high enough to increase survival probability. Direct contact transmissions through sexual or general contact such as in DFTD and CVTD ensures a higher potential for transmission. Population factors also play an important role. A dense population of available and uninfected potential hosts is ideal for the tumors given the complexity and difficulty of the overall process, hence its virulence and potency must be adequately controlled. ==Humans==

In humans, a significant fraction of Kaposi's sarcoma occurring after transplantation may be due to tumorous outgrowth of donor cells. Although Kaposi's sarcoma is caused by a virus (Kaposi's sarcoma-associated herpesvirus), in these cases, it appears likely that transmission of virus-infected tumor cells—rather than the free virus—caused tumors in the transplant recipients. In 2014, a case of parasite-to-host cancer transmission occurred in a 41-year-old man in Colombia with a compromised immune system due to HIV. The man's tumor cells were shown to have originated from the dwarf tapeworm, Hymenolepis nana. In the 1990s, an undifferentiated pleomorphic sarcoma was transmitted from a 32-year-old patient to his 53-year-old surgeon when the surgeon injured his hand during an operation. Within five months, a tumor had developed on the hand of the surgeon and was subsequently excised. Histologic examinations of the tumor tissues from the patient and surgeon showed that both were morphologically identical. In 1986, a 19-year-old laboratory worker mistakenly punctured her hand with a needle previously used to extract human colonic cancer cells. No injection of the substance occurred, and the worker suffered a small puncture wound with bleeding. Within 19 days, she had developed a small cancerous nodule on her hand. The tumor was removed soon after, and showed no sign of subsequent reoccurrence. ==Other animals==

Contagious cancers are known to occur in dogs, Tasmanian devils, Syrian hamsters, and some marine bivalves including soft-shell clams. These cancers have a relatively stable genome as they are transmitted. Recent studies have tested whether other highly prevalent wildlife cancers, such as urogenital carcinomas in Californian sea lions, could also be contagious but so far there is no evidence for this. Clonally transmissible cancer, caused by a clone of malignant cells rather than a virus, is an extremely rare disease modality, with few transmissible cancers being known. Animals that have undergone population bottlenecks may be at greater risks of contracting transmissible cancers due to a lack of overall genetic diversity. Infectious cancers may also evolve to circumvent immune response by means of natural selection in order to spread. Because of their transmission, it was initially thought that these diseases were caused by the transfer of oncoviruses, in the manner of cervical cancer caused by human papillomavirus. Canine transmissible venereal tumor Canine transmissible venereal tumor (CTVT) is sexually transmitted cancer which induces cancerous tumors on the genitalia of both male and female dogs, typically during mating. It was first described medically by a veterinary practitioner in London in 1810. It was experimentally transplanted between dogs in 1876 by M. A. Novinsky (1841–1914). A single malignant clone of CTVT cells has colonized dogs worldwide, representing the oldest known malignant cell line in continuous propagation, a fact that was uncovered in 2006. Researchers deduced that the CTVT went through 2 million mutations to reach its actual state, and inferred it started to develop in ancient dog species 11 000 years ago. can be transmitted from one Syrian hamster to another through various mechanisms. It has been seen to spread within a laboratory population, presumably through gnawing at tumours and cannibalism. Devil facial tumour disease Devil facial tumour disease (DFTD) is a transmissible parasitic cancer in the Tasmanian devil. Since its discovery in 1996, DFTD has spread and infected 4/5 of all Tasmanian devils and threatens them with extinction. DFTD has a near 100% fatality rate, and has killed up to 90% of Tasmanian devil populations living in some reserves. A new DFTD tumor-type cancer was recently uncovered on 5 Tasmanian devils (DFT2), histologically different from DFT1, leading researchers to believe that the Tasmanian devil "is particularly prone to the emergence of transmissible cancers". The cells have infected clam beds hundreds of miles from each other, making this clonally transmissible cancer the only one that does not require contact for transmission. Clinocardium also suffers from a transmissible cancer, which has a significant economic impact. == See also ==