Jacksonville Jaguars 2021 season Etienne officially declared for the
2021 NFL draft in January 2021. He was selected by the
Jacksonville Jaguars with the 25th overall selection, which they previously obtained from a trade that sent
Jalen Ramsey to the
Los Angeles Rams. This reunited Etienne with his college quarterback
Trevor Lawrence, who was taken by the Jaguars first overall in the same draft. On May 15, Jaguars coach
Urban Meyer announced that Etienne would spend the Jaguars minicamp as a
wide receiver, rather than a
running back. On July 19, 2021, Etienne signed his four-year rookie contract with the Jaguars, worth $12.9 million. During the Jaguars second preseason game against the
New Orleans Saints, Etienne suffered a Lisfranc injury and was subsequently ruled out indefinitely. It was later revealed that Etienne had suffered a significant tear in the lisfranc zone of his foot, which required surgery, and prematurely ended his 2021 season. He was placed on season-ending injured reserve later in the day.
2022 season Etienne made his professional debut in the Jaguars' 2022 season opener against the
Washington Commanders and had four carries for 47 rushing yards. Etienne recorded his first career touchdown in Week 7 against the
New York Giants, adding 14 carries for 114 yards and 1 lost fumble in the 23–17 loss. This marked the first time in his NFL career that he recorded a touchdown and over 100 yards in an NFL game. In the following game, he recorded 24 carries for 156 rushing yards and one rushing touchdown in the 21–17 loss to the
Denver Broncos. He had 28 carries for 109 rushing yards and two rushing touchdowns in the next game against the
Las Vegas Raiders, a 27–20 victory. He had two more games over the 100-yard mark on the season, in Week 15 against the
Dallas Cowboys and Week 17 against the
Houston Texans. In the
Wild Card Round against the
Los Angeles Chargers, he had 20 carries for 109 rushing yards in the 31–30 victory. On the Jaguars' final drive, Etienne had a 25-yard run on fourth down to set up the game-winning field goal attempt.
2023 season During Week 5 against the Buffalo Bills at
Tottenham Hotspur Stadium, Etienne finished with 136 rushing yards and two touchdowns as the Jaguars won 25–20. He finished the season with 267 carries for 1,008 rushing yards and 11 touchdowns.
2024 season On April 29, 2024, the Jaguars picked up the fifth-year option on Etienne's contract. He finished the 2024 season with 150 carries for 558 rushing yards and two rushing touchdowns to go with 39 receptions for 254 receiving yards.
2025 season In the season opener, Etienne had 16 carries for 143 yards in a 26–10 win over the Carolina Panthers. He had 19 carries for 124 yards and a touchdown in a 26–21 win over the 49ers in Week 6. In Week 15, against the Jets, he had three receiving touchdowns in the 48–20 win. Etienne bounced back in the 2025 season, finishing the year with 1,107 rushing yards and seven rushing touchdowns on 260 carries. He also set a career high in receiving touchdowns with six. He had a receiving touchdown to go with 116 scrimmage yards in the 27–24 loss to the Bills in the Wild Card Round.
New Orleans Saints On March 13, 2026, Etienne signed a four-year, $52 million contract with the
New Orleans Saints. ==Career statistics==