Travoprost

Travoprost is used to treat high pressure inside the eye including glaucoma. Specifically it is used for open angle glaucoma when other agents are not sufficient. ==Side effects==

Possible side effects are: • blurred vision • eyelid redness • permanent darkening of eyelashes • eye discomfort • permanent darkening of the iris to brown (heterochromia) • burning sensation during use • thickening of the eyelashes • inflammation of the prostate gland, restricting urine flow (BPH) Research suggests that wiping the eye with an absorbent pad after the administration of eye drops can result in shorter eyelashes and a lesser chance of hyperpigmentation in the eyelid, compared to not wiping off excess fluid. ==Pharmacology==

Mechanism of action It is a synthetic prostaglandin analog (or more specifically, an analog of prostaglandin F2α) that works by increasing the outflow of aqueous fluid from the eyes. Like other analogs of prostaglandin F2α such as tafluprost and latanoprost, travoprost is an ester prodrug of the free acid, which acts as an agonist at the prostaglandin F receptor, increasing outflow of aqueous fluid from the eye and thus lowering intraocular pressure. ), 1,2-dinortravoprost acid, 1,2,3,4-tetranortravoprost acid. Below: reduction of the 13,14-double bond (red) and oxidation of the 15-hydroxy group (blue) == References ==