•
Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s. •
Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first
typical antipsychotic. •
Imipramine, originally investigated as an antipsychotic, was discovered in the early 1950s, and was the first
tricyclic antidepressant. •
Carbamazepine was discovered in 1953, and was subsequently introduced as an anticonvulsant in 1965. •
Clozapine, a derivative of imipramine, was synthesized in 1958 and entered the European market in 1972 under the name
Leponex. • Antidepressants with a tetracyclic structure such as
mianserin and
maprotiline were first developed in the 1970s as
tetracyclic antidepressants. •
Loratadine was introduced as a non-sedating second generation antihistamine in the 1990s. ==Gallery==