tRNAdb was a comprehensive biological database of transfer RNA (tRNA) sequences and tRNA genes. It originated as one of the first specialized compilations of nucleic acid sequences, starting as a print publication by Mathias Sprinzl in the late 1970s. It evolved into a web-based resource hosted at the University of Bayreuth and was later relaunched in 2009 as a more powerful relational database at the University of Leipzig. The database is now considered defunct, as the Leipzig-based resource is no longer active. Its role has largely been superseded by other modern tRNA databases.