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Troponin C

Troponin C (TN-C or TnC) is a protein which is part of the troponin complex. There are two versions (paralogs) in humans. It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with actin and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of troponin I after calcium binding.

Isoforms
The tissue specific subtypes are: • Slow troponin C, TNNC1 (3p21.1 ) • Fast troponin C, TNNC2 (20q12-q13.11, ) == See also ==
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