On 23 February 2018, it was announced that
Trust Me would return for a second series, featuring a new premise and an entirely new cast owing to Jodie Whittaker's casting as the
Thirteenth Doctor in
Doctor Who. The second series was set on the neurological unit of South Lothian Hospital, following Syrian tour veteran Corporal James 'Jamie' McCain as he recovers from spinal injuries and psychological trauma whilst facing a potential new enemy as patients unexpectedly die around him. The second series premiered on 16 April 2019. On 27 June 2019, the BBC confirmed that
Trust Me had been cancelled. ==Episodes==