The Cove of the Withlacoochee was occupied by
Indigenous peoples of Florida for many centuries. As of 1984, 30 archaeological sites had been identified in the area, with evidence of occupation by people of the
Deptford,
Weeden Island, and
Safety Harbor cultures. The
de Soto expedition crossed the middle section of the Cove in 1539 before reaching the
Timucua town of
Ocale. The Duval Island archaeological site (8Ci5), at the southern end of the Cove, is a likely location for the town of Tocaste named in the chronicles of the de Soto expedition. Another archaeological site, Tatham Mound (8Ci203), contained burials of a few people killed by sword blows, and of at least 77 individuals who apparently died at close to the same time, perhaps from an epidemic disease introduce by the de Soto expedition. The area supported a large
Seminole population before and during the
Second Seminole War. The Wild Hog Scrub archaeological site (8Ci198) has been tentatively identified as Powell's Town,
Osceola's home at the beginning of the Second Seminole War. The Cove was a focus of military activity in the first year of the Second Seminole War, with large U.S. forces attacking the Seminoles there in December 1835, February–March 1836 and October–November 1836. ==Notes==