Spears was selected by the
Tennessee Titans in the third round, 81st overall, of the
2023 NFL draft. He shared a backfield that had
Derrick Henry as the primary running back. In Week 5, against the
Indianapolis Colts, he scored his first professional touchdown on a 19-yard rush. He finished his rookie season with 453 rushing yards and two touchdowns along with 52 catches for 385 yards and one touchdown. Spears returned for the
2024 season, now sharing the backfield with newly signed
Tony Pollard after Henry's departure. He was the only Titans player that season to record two touchdowns in two consecutive games during Week 15 and Week 16. He appeared in 12 games, missing parts of the season due to injury. He finished the season with 84 carries for 312 rushing yards and four rushing touchdowns, along with 30 receptions for 224 yards and a receiving touchdown. Spears missed the first four games of the 2025 season due to an ankle injury. On October 4, 2025, Spears was activated off of the
injured reserve list. ==NFL career statistics==