Iowa Highway 163 begins at the corner of E. 14th Street, which carries
U.S. Highway 69 (US 69), and E. University Avenue in
Des Moines. It heads east along E. University traveling to
Interstate 235 (I-235). There is no direct access to eastbound I-235 from eastbound Iowa 163. Traffic must take E. 21st Street to Easton Boulevard to access eastbound I-235. Highway 163 continues east past the
Iowa State Fairgrounds on its way to
Pleasant Hill where it meets
U.S. Highway 65 at a
diamond interchange. It continues east and meets
Iowa Highway 117 near
Prairie City. It turns southeast and meets
Iowa Highway 14 near
Monroe. It continues southeast, passes
Pella, then continues southeast, meeting
Iowa Highway 92 west of
Oskaloosa before intersecting
U.S. Highway 63 south of that city. The Iowa 163 designation is then extended along U.S. Highway 63 between Oskaloosa and
Ottumwa, and
U.S. Highway 34 between Ottumwa and Burlington. ==History==