Florida US 129 begins at US 19/US 27 Alternate/US 98 in Chiefland, Florida, along hidden
SR 47 until it reaches
SR 26 in
Trenton. From there, the road is signed along hidden
SR 49. It then moves west, briefly overlapping
US 27 (hidden
SR 20) and heads north again in
Branford, before that road intersects
SR 349, which used to also serve as
US 129 Alternate. From here, it intersects with
US 90/
SR 51 in
Live Oak, taking SR 51 as the new hidden state road, then meets
I-10 at exit 283, and later
I-75 at exit 451. During a concurrency with
US 41 in
Jasper, US 129 loses SR 51 as a hidden route after the concurrency ends and runs northwest along
SR 100 into Georgia.
Georgia US 129 provides the primary route between
central Georgia and
Athens. It approaches Athens from the south where it joins
SR 10 Loop, a mostly interstate-grade bypass that rings
Athens-Clarke County. Here US 129 turns right, toward the northeast, where it runs concurrently with
US 78/
US 29/
US 441/
SR 15 (and unsigned
SR 422) along the bypass. US 129 intersects with US 29 northeast of Athens and continues along SR 10 Loop westward before exiting at Jefferson Road where it winds northwesterly towards
Gainesville as one of several routes to
I-85 from Athens.
North Carolina From the Georgia state line, it travels northeast to
Topton, where it goes north to
Robbinsville followed by
Tennessee, through Deals Gap.
Tennessee US 129 enters Tennessee to the west of
Great Smoky Mountains National Park and rides along
Chilhowee Lake for a short distance before turning due north. In this stretch after the Tennessee–North Carolina state line, drivers will encounter 318 curves in a distance of around 11 miles. These curves make this stretch of highway a well-known motorcycle/sports car destination named Tail Of The Dragon. On weekends, through spring to the fall months, visitors are likely to see numerous riders and drivers on this stretch of the highway to experience the thrill and scenery. US 129 then travels due north, becoming known as
Alcoa Highway and passing through the city of
Maryville. It travels through
Alcoa, passing by
McGhee Tyson Airport, and then intersecting
I-140. US 129 then crosses the
Tennessee River on the
James E. "Buck" Karnes Bridge into
Knoxville. Shortly thereafter, US 129 becomes a
limited-access highway for a short distance. It has an interchange with
US 11/
US 70 immediately after entering Knoxville. Shortly thereafter, US 129 meets its northern terminus, an interchange with
I-40. ==Major intersections==