U.S. Route 266 is a 43.09-mile (69.35 km), east–west U.S. Numbered Highway in Okmulgee, McIntosh, and Muskogee counties in Oklahoma, United States, that connects U.S. Route 62 and U.S. Route 75 in Henryetta with U.S. Route 64 in Warner. The highway no longer meets the former route of its parent, U.S. Route 66, and is closely paralleled by Interstate 40 (I-40), which replaced US 266 as the major east–west highway east of Oklahoma City during the 1960s.