US 49W begins just north of downtown
Yazoo City at an interchange between US 49 and
US 49E. It heads northwest to have an interchange with and become concurrent with
MS 3 before leaving Yazoo City and crossing over the
Yazoo River. The highway then crosses into
Humphreys County just southwest of
Carter. US 49W/MS 3 now cross over the
Will M. Whittington Auxiliary Channel and
Lake Atchaflya before passing through
Silver City and having an intersection with
MS 149. The highway continues north, paralleling the Yazoo River, to pass through
Belzoni, where it bypasses downtown along its west side and has a short concurrency with
MS 12 and an intersection with
MS 7. US 49W/MS 3 continue northwest to pass through
Isola, where it has an intersection with unsigned
MS 806 (Belzoni Street) and crosses over
Lake Dawson, before entering
Sunflower County. The highway passes through
Caile and
Inverness, where it intersects another section of MS 149, before MS 3 splits off towards
Moorhead near
Baird. US 49W crosses over the
Sunflower River to enter
Indianola. It bypasses downtown along its east side, passing through neighborhoods to have an intersection with
US 82. The highway then narrows to two-lanes to leave Indianola and cross the Sunflower River for a second time. Prior to this point, the entire route of US 49W is a four-lane highway. US 49W passes through
Sunflower, where it intersects unsigned
MS 810 and rejoins MS 3, before passing through Dwyer and
Blaine. US 49W/MS 3 passes through
Doddsville, where it has a short concurrency with
MS 442 and intersects unsigned
MS 832, and
Cottondale before passing through
Ruleville, where it has an intersection with unsigned
MS 812 and
MS 8. The highway passes through
Drew, where it intersects unsigned
MS 820, before passing by the
Mississippi State Penitentiary, where it has an intersection with
MS 32. US 49W/MS 3 passes through
Rome before cutting a corner of
Coahoma County. Soon after, the route reaches
Tallahatchie County. The highway passes northeast through rural areas for several miles before entering
Tutwiler and coming to an end at a Y-Intersection between US 49 and US 49E, with MS 3 continuing north along US 49. ==History==