US 50 Business begins at a partial interchange with US 50, with ramps from US 50 east to US 50 Business east and US 50 Business west to US 50 west. One lane of westbound US 50 Business continues beyond the ramp to an intersection with Stanton Avenue, a service road for residences detached from US 50 when the interchange was built. The movements missing from the interchange are completed via Naylor Mill Road just to the east of the partial interchange. US 50 Business heads southeast toward downtown Salisbury as a four-lane divided highway. After passing American Legion Road, the business route enters the city limits of Salisbury and its name changes to Salisbury Parkway. At the intersection with MD 349 (Nanticoke Road) and Isabella Street, US 50 Business turns east, expands to six lanes, becomes a partially
controlled access highway, and begins to parallel Main Street, the original alignment of US 50. After crossing the North Prong of the
Wicomico River on a
drawbridge, the business route intersects Division Street, the original alignment of US 13. The highway drops to four lanes as ramps to Baptist Street heading eastbound and from Broad Street heading westbound leave the highway; these streets are used to access US 13 Business (Salisbury Boulevard). US 50 Business expands to six lanes again after passing under US 13 Business and the Delmarva Subdivision track of the
Delmarva Central Railroad. The business route returns to four lanes after the intersection with MD 346 (Main Street), which is the original alignment of US 50. The median expands as US 50 Business passes commercial and industrial properties. A
park and ride lot is located at the southeast corner of the Phillip Morris Drive intersection. Shortly after the intersection with Tilghman Road, the business route reaches its eastern terminus at a
partial cloverleaf interchange with the Salisbury Bypass, which features US 13 and US 50 west. The divided highway continues east as US 50 (Ocean Gateway) toward
Ocean City. US 50 Business is a part of the
National Highway System as a principal arterial for its entire length. ==History==