US 51 enters Illinois from Kentucky at
Cairo, Illinois. The highway heads northbound to
Mounds, near Cairo, and begins to overlap
Interstate 57 (I-57), following it for to
Dongola, before splitting and heading north. The highway remains two lanes wide from Dongola to
Assumption with the exception of a section between
Centralia and
I-64. Past Assumption, US 51 becomes an expressway to
Decatur. In Decatur, US 51 follows
I-72 to bypass the city. US 51 leaves I-72 after , and it heads north to
Bloomington–
Normal as an expressway. At Bloomington–Normal, US 51 follows
I-74 for a mile, then
I-55 for , before following
I-39 for . US 51 follows I-39, intersecting
I-80 and
I-88 along the way. The highway also follows
US 20 south of
Rockford (while still following I-39). I-39/US-51 join
I-90, making US 51 one of the few toll highways in Illinois that is a U.S. Highway. US 51 exits I-39/I-90 just a mile south of the Wisconsin state line. Then US 51 follows
Illinois Route 75 (IL 75) west to the intersection of
IL 251, and then turns north through
South Beloit, Illinois to enter Wisconsin. ==History==