In the following, the direction is from southwest to northwest in line with the direction in which the line was built. The route begins in the southwest of Nuremberg at
Röthenbach station, at the western end of a three-track parking and turning system, and continues east along the Schweinauer Hauptstraße under the
Main-Danube Canal and the
:de:Südwesttangente highway (southwestern tangential road) to the station
Hohe Marter. This station is the longest in the Nuremberg subway network with and replaces the two abandoned tram stops Friesenstraße and Schweinau, which were formerly located at the two present-day subway exits. The route continues under Schweinauer Hauptstraße to
Schweinau station and
St. Leonhard station, which, due to its location in the middle of Schweinauer Straße, is completely elastic so as not to give off the vibrations caused by driving to the surrounding houses. Next is the
Rothenburger Straße station beneath the
Frankenschnellweg (A73). Rothenburger Straße station marks the beginning of the shared trunk line between U2 and U3 and is also served by
S1 of the
Nuremberg S-Bahn. Consequently, a lot of interchanging traffic uses this station. The last part of the southern half of the route runs in a curve under the Obere Kanalstraße and then leads in a right arc to the
Plärrer station, where the U2 meets the U1. The Plärrer is an old interchange point for all kinds of transportation and was served by
Germany's first railway and at times over a dozen tram lines. As of 2024 it is served by all Nuremberg subway lines and three (out of seven)
Nuremberg tram lines. After the station Plärrer the route runs under the Frauentorgraben to
Opernhaus station. During the construction of this station which is close to the former city wall, the former
moat which had been filled in was restored and thus the station has open air access and natural light to one side. The former moat has been pedestrianized. The route continues to
Nuremberg Hauptbahnhof, serving the other main interchange point (all subway lines; 3 out of 5 tram lines) in the network besides Plärrer. Afterwards the line heads north to the
Wöhrder Wiese station. Due to its location in the valley of the river
Pegnitz, the station had to be lowered and the northern branch of the Pegnitz had to be incorporated into the station building, which can be seen in the relatively low ceiling, which extends across the entire station. The following route runs under the Laufertorgraben and steeply climbs towards
Rathenauplatz station, which can be observed in the station itself, as the ceiling from the southern to the northern platform has a significant difference in height. Rathenauplatz station named for the slain politician and industrialist
Walther Rathenau is the last station U2 shares with U3 and also allows interchange with tram line 8, making it one of the busiest stations in the network. After the Rathenauplatz station, the route initially runs under the Bayreuther Straße, turns right to the
Rennweg station under the street of the same name and continues under Schoppershofstraße to the
Schoppershof station. Between this and the following station
Nordostbahnhof under the Leipziger Platz the two tracks run together in the same single bore tunnel. This is opposed to most of the rest of the line where the two tracks run in separate tunnels. Nordostbahnhof is also served by the Nürnberg-Gräfenberg mainline railway and the U2 serves as a connection for mainline rail passengers between this line and the rest of the network as there is no revenue service from Nordostbahnhof to stations on any other mainline railway. There is a parking and turning system under the Bessemerstraße in a tube shared with the city-side track. After that the station
Herrnhütte station is found at the junction with the Äußere Bayreuther Straße. Then the route takes a narrow counter arc under housing development to the station
Ziegelstein beneath Fritz Munkert Platz, at whose northern end is another parking and turning system. The two railway tracks are then merged and run as a single-track tunnel in a westerly direction to the terminus station serving the airport. Due to the long single track section between Ziegelstein and Airport, only one train every ten minutes continues to the airport with most trains during the day terminating at Ziegelstein. This was formerly indicated by short terminating trains being indicated as "U21". The station serving the airport has two platform tracks but usually only one is used for passenger service. Occasionally a train with minor defects or awaiting a later departure will wait on the mostly unused second platform track. ==Stations==