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UDP-3-O-acyl-N-acetylglucosamine deacetylase

UDP-3-O-acyl-N-acetylglucosamine deacetylase, also known as LpxC, is a zinc-dependent enzyme involved in bacterial lipid A biosynthesis, catalyzing the removal of the acetyl group from UDP-3-O-acyl-N-acetylglucosamine, a key step in the production of lipopolysaccharides in the outer membrane of gram-negative bacteria.

Nomenclature
UDP-3-O-acyl-N-acetylglucosamine deacetylase is also known as: • UDP-3-O-((3R)-3-hydroxymyristoyl)-N-acetylglucosamine amidohydrolase • LpxC enzyme • LpxC deacetylase • deacetylase LpxC • UDP-3-O-acyl-GlcNAc deacetylase • UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase • UDP-(3-O-acyl)-N-acetylglucosamine deacetylase • UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase • UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase) ==Inhibitors==
Inhibitors
Various inhibitors of LpxC have been developed as potential antibiotics, though none have yet reached clinical trials. • ACHN-975 • CHIR-090 • CS250 • LPC-233 • PF-5081090 • TP0586532 == References ==
Source: Wikipedia ↗
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