A heavyweight bout between former
UFC Heavyweight Championship challenger
Derrick Lewis and
Aleksei Oleinik took place as the event headliner. However, the bout was rescheduled for
UFC Fight Night: Overeem vs. Sakai after Montaño's coach, John Wood,
tested positive for COVID-19. A women's bantamweight bout between
Ketlen Vieira and former
Invicta FC Bantamweight Champion and
UFC Women's Featherweight Championship challenger
Yana Kunitskaya was originally scheduled for a week earlier at
UFC Fight Night: Brunson vs. Shahbazyan. However, it eventually moved to this event instead. Subsequently, Vieira was removed from the card on July 30 due to
visa issues and replaced by returning veteran
Julija Stoliarenko, who was the current Invicta FC Bantamweight Champion. Vieira was then expected to face a different opponent at
UFC Fight Night: Waterson vs. Hill on September 12. A heavyweight bout between
Sergei Pavlovich and
Ciryl Gane was expected to take place at this event. However, Pavlovich pulled out on July 15 due to an old knee injury that required surgery. He was replaced by
Shamil Abdurakhimov and the bout moved to
UFC 253. Gane and Abdurakhimov were originally scheduled for
UFC 249, but Gane was forced to pull out of the event after he was struck by a
pneumothorax in training. Subsequently, the bout would be rescheduled for
UFC 251. However, it was then cancelled a second time as Abdurakhimov was removed from the card for undisclosed reasons. A couple of fights, including a women's strawweight bout between
Nadia Kassem and Miranda Granger, as well as a featherweight bout between
Alex Caceres and
Giga Chikadze were expected to take place at this event. However, they never made it to the final card for unknown reasons. At the weigh-ins,
Beneil Dariush and
Laureano Staropoli missed weight for their respective bouts. Dariush weighed in at 158 pounds, two pounds over the lightweight non-title fight limit. Staropoli weighed in at 174.5 pounds, three and a half pounds over the welterweight non-title fight limit. Both of their bouts proceeded at a catchweight and they were each fined 20% of their individual purses, which went to their opponents
Scott Holtzman and
Tim Means (Means was given one additional hour to make weight after initially weighing 172.5 pounds). ==Results==