The event marked the promotion's first visit to Chile. A welterweight bout between
The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner
Kamaru Usman and
Santiago Ponzinibbio was expected to serve as the event headliner. However, Ponzinibbio pulled out on April 21 due to injury. He was replaced by former
UFC Welterweight and
Middleweight Championship challenger
Demian Maia. A flyweight bout between former
UFC Flyweight Championship challenger
Ray Borg and
Brandon Moreno was originally expected to take place at
UFC Fight Night: Cowboy vs. Medeiros. However, due to a minor injury sustained by Moreno, the pairing was postponed and rescheduled to take place at
UFC 223. The bout was delayed again, after Borg had issues related to glass shards in his eye as a result of the former
UFC Featherweight and
Lightweight Champion Conor McGregor and crew
bus melee. The pairing was scheduled again and was expected to take place at this event. However, Borg withdrew from the bout to take care of his child, who required brain surgery. He was replaced by
Alexandre Pantoja. A light heavyweight bout between former
UFC Light Heavyweight Champion Maurício Rua and former title challenger
Volkan Oezdemir was expected to take place at this event. However, it was reported on April 13, 2018, that Oezdemir was pulled from the event due to alleged
visa issues stemming from a previous legal transgression, restricting his travel to Chile. The pairing was left intact and rescheduled for July 22, 2018, at
UFC Fight Night: Volkan vs. Shogun. ==Results==