The event marked the promotion's third visit to San Antonio and first since
UFC on ESPN: dos Anjos vs. Edwards in July 2019. They were previously expected to headline
UFC Fight Night: Andrade vs. Blanchfield, but were rescheduled to this event for unknown reasons. Although it was not announced by the promotion, a rematch between
Irene Aldana and former
UFC Women's Bantamweight Championship challenger
Raquel Pennington was originally rumored to headline this event. The pair previously met at
UFC on ESPN: dos Anjos vs. Edwards, where Pennington won by a split decision. However, the bout never materialized.
Sean Brady and
Michel Pereira were expected to meet in a welterweight bout. However, Brady pulled out in mid-February due to a torn groin and the bout was scrapped. A featherweight bout between
Alex Caceres and
Nate Landwehr was expected to take place at the event. However, Caceres withdrew due to an undisclosed reason and was replaced by
Austin Lingo. Liang Na and
Brogan Walker-Sanchez were expected to meet in a women's flyweight bout. However, Liang pulled out due to undisclosed reasons and Walker-Sanchez was moved to
UFC Fight Night: Pavlovich vs. Blaydes a month later as a replacement against Iasmin Lucindo. Tamires Vidal was expected to face Hailey Cowan in a women's bantamweight bout at the event. However, Vidal pulled out due to undisclosed medical reasons and the pairing was scrapped. A lightweight bout between
Manuel Torres and Trey Ogden was expected to take place at the event, but it was cancelled the day before due to Torres suffering a medical issue. Former
UFC Flyweight Championship challenger
Alex Perez and former
Rizin Bantamweight Champion Manel Kape were expected to meet on the main card. However, the pairing was cancelled during the broadcast as Perez suffered a seizure backstage. During the event's broadcast, former
UFC Lightweight Championship challenger
Donald Cerrone was announced as the next "modern wing"
UFC Hall of Fame inductee. ==Results==