Uithuizen was first mentioned in 1000 as Uthuson (extreme houses). It was established by the inhabitants of as their furthest edge. Around 1200, a
dike was built to protect the village. In the mid-19th century, Uithuizen started to grow substantially. In the village is a
borg called the
Menkemaborg. Menkemaborg at Uithuizen is a 14th-century, brick-built country house, which was substantially altered around 1700. In 2000 a new sports centre was built on the site of the former station building at Uithuizen railway station. On 17 May 2008,
Cardinal Simonis opened the Trail of St James, connecting Uithuizen to
Hasselt,
Le Puy en Velay, and
Santiago de Compostela, creating a modern, northern branch of the
Way of St James. Uithuizen hosted the finish of stage 4 at the
2013 Energiewacht Tour. ==Economy==