Prior to the album's release, the songs "Rose Petal" and "Envy" were released as singles. Both singles charted on the
Billboard Mainstream Rock chart, and both also peaked at the same position of No. 32. Although Twiztid had appeared on numerous album charts in the past, the two singles were the first time that the duo had appeared on a singles chart.
Unlikely Prescription was released on September 10, 2021. It peaked at No. 16 on the
Billboard Top Album Sales chart and, because of the duo's venture into the rock genre, at No. 20 on the
Billboard Top Hard Rock Albums chart, which was their first appearance on the chart. It also peaked at No. 14 on the
Billboard Top Current Album Sales chart as well; however, similar to 2020's
Revelashen, the album failed to appear on
Billboard′s
Top Independent Albums or
Billboard 200 charts (which every album prior to
Revelashen had done so on one or the other). ==Track listing==