Barberini was married three times.
Cornelia Zeno Ottoboni In 1691 he married Cornelia Zeno Ottoboni (sister of Cardinal
Pietro Ottoboni). Her
last will and testament gives some idea of the wealth the Barberini had amassed under Urbano's grandfather,
Taddeo Barberini and his brothers who had all benefited from their uncle
Pope Urban VIII's famous
nepotism.
Felice Ventimiglia Pignatelli d'Aragona In 1693 he married Felice Ventimiglia Pignatelli d'Aragona. It was an unhappy marriage for both parties. Though they had a son, a much-awaited legitimate heir for the Barberini house, he died at the age of three. The two separated and she sought refuge with her brother-in-law, Urbano's Cardinal brother Francesco and later joined a convent within his bishopric. Her dowry, later her legacy upon her death, was left to Francesco. Neither she nor Urbano made mention of each other in their respective wills.
Maria Teresa Boncompagni In 1714, now 50 years old and still without a legitimate male heir, Barberini married 22-year-old Donna Maria Teresa Boncompagni (daughter of
Gregorio II Boncompagni,
Duke of Sora, and wife
Ippolita Ludovisi). They had one daughter, Cornelia Costanza Barberini. When she was 12 years old, Urbano's brother Francesco encouraged her to marry Giulio Cesare Colonna di Sciarra. Maria Teresa wanted her daughter to remain with her at the
Palazzo Barberini until she was of an age to choose her husband. Cardinal Francesco, in an effort to maintain to Barbarini heritage, wanted his niece to be educated at a convent of his choosing until she was old enough to marry a husband, also of his choosing. Eventually Cornelia Constance Barberini, Urbano Barberini's only legitimate heir, married Giulio Cesare Colonna di Sciarra, giving origin to the Barberini-Colonna di Sciarra, Princes of Carbognano, Dukes of Bassanello, Montelibretti and Anticoli Corrado, etc, and the Barberini-Colonna, Princes of Palestrina, Dukes of Castel Vecchio, etc, families. ==Maffeo Callisto Barberini==