South Carolina US 21 travels through the state. Beginning at
Hunting Island State Park, US 21 travels west toward Beaufort, where it widens to four lanes. The route bypasses Beaufort to the south, going through
Port Royal,
Shell Point, and
Burton. In the Beaufort area, US 21 passes by the entrances to
Parris Island and
Marine Corps Air Station Beaufort, the major Marine Corps installations in the area. North of Beaufort, US 21 continues as a four-lane
divided highway and intersects with
US 17. The route travels in a
wrong-way concurrency with US 17 south for before turning north toward
Yemassee, where it becomes a rural two-lane road and intersects with
US 17 Alternate. North of Yemassee, US 21 splits off and crosses
I-95 at exit 42. The two-lane route continues through rural portions of the state. US 21 goes through
Smoaks and
Branchville and bypasses
Orangeburg. North of Orangeburg, US 21 runs roughly parallel to
I-26 until
Gaston where it conjoins
US 321 and becomes an urban highway. US 21 passes through
Cayce,
West Columbia, and
Columbia. North of Columbia, US 21 splits from US 321, reverting to a rural two-lane road parallel to
I-77. In
York County, US 21 enters urban areas again, connecting
Rock Hill and
Fort Mill. Near the
North Carolina state line, US 21 merges with I-77 near
Carowinds, then enters North Carolina.
North Carolina US 21 begins as a
concurrency with
I-77 in
Charlotte, which it repeats three times within the state. Its first break with I-77 is along Statesville Avenue, then proceeding through
Huntersville and
Cornelius, however, because of its close proximity to I-77 and
North Carolina Highway 115 (NC 115), it has no interchange with
I-485 by itself. The second break with I-77 occurs at
Mooresville, where US 21 travels through the city and then northwest into
Statesville. After Statesville, US 21 travels northeast to
Harmony and
Brooks Crossroads, before merging back with I-77 near
Jonesville. However, Jonesville and
Elkin connect with
US 21 Bus. through centers of both towns, as an alternate route paralleling I-77. North of Elkin, US 21 splits with I-77 for the last time and goes north to
Sparta, passing the
Blue Ridge Parkway after a major, curvy section. North of Sparta, at
Twin Oaks,
US 221 overlaps with US 21 before entering
Virginia. US 21 travels through the western Piedmont of North Carolina, either combined with I-77 or as a two-lane rural road; from the South Carolina state line to Elkin, travelers can easily skip a majority of US 21 via I-77.
Virginia (SR 805) in Grayson County, Virginia After a few miles crossing the state line, US 21 reaches the town of
Independence, where it splits with US 221 and continues north. The route goes through the
Mount Rogers National Recreation Area before entering the city of
Wytheville. After a short concurrency with
US 11 in downtown Wytheville, it goes north and ends at the intersection of
I-81/
US 52. US 21 travels through western Virginia, mostly as a two-lane rural mountain road. ==History==